Zinc Deficiency and Histamine Intolerance
You may remember zinc from its roles in neon-coloured 90s sun protection and fighting a cold, but it also plays a part in another important aspect of immunity: allergic responses and histamine intolerance.
At Health & Wellness AU & NZ, our Naturopaths specialise is a natural allergy treatment called Positive Association Technique (PAT), so work with many clients struggling with allergy and histamine symptoms.
So while it’s not the cure-all for allergies, the link between allergic immune responses, zinc deficiency and histamine intolerance is worth exploring, so let’s break it down.
What does Zinc Actually do?
Zinc is the second most abundant trace element in the body, after iron, with over 300 enzymes relying on zinc to function. It is also labelled as “essential”, being a nutrient that the body can’t make or store. This means if we aren’t getting it from our diet, we aren’t getting it at all.
On a cellular level, zinc is involved in making proteins and DNA, and cell division and differentiation. This alone means zinc has wide reaching actions in the body and is heavily involved in many aspects of health, including:
- Maintaining healthy skin and gut barrier
- Wound healing and collagen production
- Immune function and inflammation control
- Taste and smell
- Bone health
- Male fertility
- Vision
- Thyroid hormone synthesis – important for many body functions, including metabolism.
- Nervous system development and function – influencing conditions such as depression and Alzheimer’s disease.
- Insulin production, stability and function – for blood sugar regulation
Zinc is a major player in gut health and the microbiome. This is important when we talk about allergies because the gut is one of our major contact points with the outside world, where potential allergens can land first. The gut barrier is a huge part of this defence, and zinc is important for maintaining it.
Zinc deficiency is linked to poor microbiome diversity and an imbalance of bacteria (dysbiosis). Zinc depletion also leads to changes in the function of the microbiome, affecting mineral absorption and the way carbohydrates are digested and fermented.
This can mean we produce less short chain fatty acids (SCFAs), which can further deplete zinc, keeping a person in a looping state of zinc-deficiency.
Finally, zinc regulates immune signalling within cells. It is involved in making antibodies, signalling inflammation, and the maturation of white blood cells.
Basically, your immune system wouldn’t do so well without it, which is why it is one of the first nutrients that will be offered when you ask a Naturopath for immune support.
Symptoms of Zinc Deficiency
There are multiple methods to test for zinc levels in the body, although it can be difficult to get a trusted, accurate result. Urine and hair tests can be helpful, though the most common test for zinc deficiency is a blood test to assess serum levels.
However, as most zinc is stored within the cell, a blood test represents less than 0.1% of total body zinc, and plasma zinc can easily fluctuate, so it is also not considered completely accurate.
Many naturopaths use the zinc tally test to give an idea of zinc deficiency. When zinc levels are low, there is also a lack of a specific zinc-dependent enzyme which affects taste perception, particularly that of zinc sulfate.
Based on this, patients are given a small dose of zinc sulfate to hold in their mouth for 30 seconds. If they cannot taste the drink it is suggested that they are deficient.
However, this doesn’t explain all cases of poor taste perception so is not entirely accurate either, but can be another helpful clue.
Basically, none of these tests alone should be considered definitive diagnostic factors. Zinc status should always take into account a proper clinical assessment of signs, symptoms and dietary intake.
Signs and symptoms of Zinc Deficiency
Zinc deficiency may present as:
- Changes in taste and smell
- Poor appetite
- Light sensitivity
- Mood swings
- Poor immunity – getting sick easily or taking longer to recover
- Diarrhoea
- Fertility challenges
- Angular cheilitis (cracks in corners of mouth)
- Skin complaints such as eczema
- Poor wound healing
- Nail changes
- Brittle, thinning hair
Causes of Zinc Deficiency
Deficiency in zinc is quite common and often it can be because we simply aren’t eating enough. However, it isn’t just a lack of intake that can cause zinc to be low.
Potential causes include:
- Low dietary intake
- Long term restrictive diets e.g. low FODMAP
- Gut issues affecting absorption like chronic diarrhoea and Coeliac disease
- Increased excretion through stool, urine, sweat, semen or menses
- Higher body demands e.g. pregnancy
- Excessive alcohol consumption
- Certain medications e.g. diuretics and angiotensin-receptor blockers
- Inflammatory conditions
Addressing these underlying causes is always important, rather than just supplementing with zinc.
Those who eat little to no meat can be at higher risk of deficiency, as red meat is one of the largest sources of zinc.
In addition, excess intake of phytates from plant-based foods such as legumes and wholegrains can bind to zinc, reducing absorption. Soaking, sprouting and fermenting can help reduce phytates and improve absorption of minerals.
Finally, when zinc is low, inflammation is activated.
However, inflammatory conditions change the balance of zinc in cells, often leading to low levels of zinc. This suggests a vicious cycle between inflammation and zinc deficiency, with one worsening the other.
So conditions of inflammation, such as allergies, could be actually be contributing to your zinc depletion.
Zinc Deficiency and Allergies
A defining factor of an allergy is an immune system which is hyperreactive to usually harmless triggers.
This sets off an immune-mediated inflammatory cascade, including T helper 2 (Th2) cells and immunoglobulin E (IgE), which activates mast cells to release histamine, most commonly resulting in respiratory, skin or gut symptoms.
What the research shows;
A link between zinc depletion and allergy development has been established. Studies show that supplementation with zinc can have a beneficial effect on moderating the immune system and decreasing allergic symptoms.
For example, a study of people with atopic (allergic) asthma found their blood zinc levels to be lower than the non-atopic asthmatics and healthy control groups. This suggests that zinc deficiency can be a risk factor for developing allergic asthma, and atopic asthmatics may respond well to zinc supplementation.
We know that zinc is a big player in the immune response. Being involved in so many different processes, including multiple different immune cells, the effects of zinc deficiency on abnormal immune function are complex.
T helper cells
Zinc is involved in helping T cells to mature. A deficiency of zinc can throw off the delicate balance of T helper cells (Th1 & Th2) by reducing Th1, which allows Th2, that involved in allergies, to be outnumbered.
Eosinophils
Eosinophils are a type of white blood cell with histamine receptors and are involved in the allergic inflammatory response. Deficiency of zinc has been shown to increase allergic inflammation from eosinophils, and a diet low in zinc significantly increased eosinophil action. Whereas zinc supplementation was shown to suppress eosinophilic inflammation and decrease eosinophil counts.
Zinc Deficiency and Histamine Intolerance
Histamine intolerance is an imbalance between histamine accumulation and clearance. This can present as hives, flushing, itching, headaches, gut symptoms and sensitivity to high histamine foods.
Many different factors can affect this balance, such as histamine production in response to allergies, histamine production by the gut microbiome, breakdown of histamine in the gut and clearance of histamine from the cells.
As zinc is involved in so many different processes from immune cell regulation to gut repair and inflammation control, the connection between zinc deficiency and histamine intolerance makes sense.
Mast cells and histamine
When an allergic reaction occurs, IgE activates mast cells and basophils to step in to trigger the allergic response, they degranulate, which releases histamine and begins the inflammatory cascade.
The main trigger for mast cells to release histamine is the intake of calcium into the cell. Zinc helps block this transfer of calcium into mast cells, therefore helping to suppress the release of histamine.
In addition, once zinc is inside the cell, it works in other ways on pathways required for mast cell degranulation, further reducing histamine production.
Zinc is also indirectly involved in the function of enzymes which break down histamine, like diamine oxidase (DAO), further driving the relationship between zinc deficiency and histamine intolerance.
Addressing Zinc Deficiency and Histamine Intolerance
First, look at your diet.
Highest food based sources of zinc include:
- Oysters
- Meat and poultry: beef, pork, turkey and chicken
- Fish and seafood, especially sardines and shrimp
- Wholegrains like oats
- Tofu
- Nuts and seeds, especially pumpkin seeds (and pepita spread!)
- Eggs
- Dairy products
- Legumes like lentils, chickpeas and beans
- Mushrooms
Soak, sprout or ferment legumes and grains to help reduce phytates and improve absorption of zinc.
Second, look at your gut.
Are gut issues getting in the way of your ability to absorb zinc? If you have chronic gut symptoms, it’s time to address them. Intestinal hyperpermeability a.k.a “leaky gut”, can allow unwanted particles from the gut into the bloodstream, increasing histamine and inflammation.
While this can be a contributor to zinc deficiency, a specific form of zinc known as zinc carnosine can be excellent remedy for gut repair. But let’s not forget we always need to look at the underlying causes as well.
Reduce your inflammatory load
If you are constantly burdened by chronic health conditions or allergies, your body may be regularly producing inflammation which can influence your zinc levels.
Positive Association Technique (PAT) helps re-train the body’s response to allergic triggers using kinesiology, acupressure and positive conditioning. By calming reactivity, we can reduce the production of histamine and inflammation, lightening the load.
Consider a supplement
Supplements are always best taken under guidance of a qualified practitioner who can help determine if you need one, and the right form and dosage for you. This is particularly true in the case of zinc.
You can have too much zinc, so it’s not one to throw in your regime for the fun of it. Excess zinc can have unwanted effects on immune function, and long term or unnecessary supplementation can also throw off levels of copper in your body.
Not all zinc is made equal, either. Well absorbed forms of zinc include zinc citrate, zinc carnosine, zinc amino acid chelate and zinc glycinate. When looking at dosage it’s important to check the ‘elemental’ level.
Another important thing to remember is zinc can cause nausea if taken on an empty stomach, so make sure you take it with or straight after food!
As you can see, the relationship between zinc deficiency and histamine intolerance, allergies, the gut and inflammation is complex!
While zinc isn’t the only piece of the puzzle, it can be an important part of the allergy and histamine intolerance picture. If you’re struggling with allergies, consider if you’re getting enough zinc to support your immune balance.
Written by Leila DiQuinzio – Melbourne based Naturopath & PAT Practitioner
Leila is a degree qualified Naturopath with over 12 years of experience, and provides Positive Association Technique (PAT) from the multi-modality clinic she co-founded in Northcote, Melbourne named ‘Aēsara Health‘.
Please note that this blog post contains general information only. Always consult your health care professional before changing your diet, starting new supplements or regarding any medical condition.











